Spike S1 Neutralizing Antibody (B.1.617.2, B.1.617.2.1, B.1.1.7, B.1.351, B.1.429, and P.1 Variants) (Clone C-A11) (SARS-CoV-2)

Catalog #

101024

$585 *

Size: 100 µg

Qty

Bulk/Custom

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Description

This purified rabbit monoclonal antibody recognizes recombinant wildtype SARS-CoV-2 Spike RBD and trimeric spike proteins. Additionally, this antibody cross-reacts with the Delta variant (B.1.617.2) Spike S1 and trimeric proteins and with the Delta Plus variant (B.1.617.2.1) trimer. This antibody also cross reacts with variant Alpha (B.1.1.7; U.K.), Beta (B.1.351; South African), and Gamma (P.1; Brazilian) Spike RBD and trimeric proteins. This neutralizing antibody impedes the interaction between SARS-CoV-2 Spike and human ACE2 receptor. ACE2 receptor is known to mediate COVID-19 infection through direct binding of the SARS-CoV2 Spike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike RBD: ACE2 Inhibitor Screening Kits and using Spike pseudotyped lentiviruses in cell-based assays.

This product has been cited 3 times.

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Synonyms

SARS neutralizing antibody, Spike S1 neutralizing antibody

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Product Data Gallery

Product Info

Storage and Usage

Citations3

Species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Purification

Protein A affinity chromatography

Format

Aqueous buffer solution

Immunogen

SARS-CoV-2 Spike RBD

150 kDa

Genbank #

MN908947

UniProt #

P0DTC2

Storage/Stability

At least 6 months at 4°C.

Assay Conditions

Experimental design and assay protocol for measuring neutralizing antibody’s functional activity using BPS Spike S1 (B.1.1.7 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit (BPS Bioscience, #78155).

Cell based neutralization assay by anti-SARS-CoV-2 Spike antibody (clone# C-A11) were conducted by followng the protocols for:

Spike (SARS-CoV-2) Pseudotyped Lentivirus (Luc reporter) (BPS Bioscience #79942)
Spike (B.1.1.7 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (Luc reporter) (BPS Bioscience #78112);
Spike (B.1.351 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (Luc reporter) (BPS Bioscience #78142);
Spike (P.1 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (Luc reporter) (BPS Bioscience #78144);
Spike (B.1.429) (SARS-CoV-2) Pseudotyped Lentivirus (Luc reporter) (BPS Bioscience #78172)

Instructions for Use

See assay protocol for detailed instructions

Shipping Temperature

+4°C

Cross Reactivity

This antibody not been tested for cross reactivity with other SARS-CoV-2 variants.

Warnings

Avoid freeze/thaw cycles

Scientific Category

Coronavirus, COVID-19

Regulatory Status

Research Use Only

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Spike S1 Neutralizing Antibody (B.1.617.2, B.1.617.2.1, B.1.1.7, B.1.351, B.1.429, and P.1 Variants) (Clone C-A11) (SARS-CoV-2)

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