Natural Killer Cells

Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cell therapies.

Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cell therapies.

Although NK cells share a common lymphoid lineage with T and B cells, they do not require prior sensitization to specific antigens and recognize and eliminate targets cells independently. They operate through a delicate balance of activating and inhibitory signals, engaging in a vigilant surveillance of the body's cells. Upon triggering of activating signals or a lack of inhibitory signals, NK cells exert their effects by releasing cytotoxic granules, expressing death ligands, driving antibody-dependent cell cytotoxicity, and producing cytokines, thereby playing a pivotal role in the early stages of immune defense and immune regulation.

The therapeutic potential of NK cells has garnered considerable attention and researchers are exploring various avenues to harness their power for clinical applications. Adoptive NK cell therapy involves isolating, expanding, and infusing ex vivo activated NK cells into patients, offering a promising approach for treating certain types of cancers. Additionally, engineering NK cells to enhance their cytotoxicity and persistence, particularly using chimeric antigen receptors (CARs), is an active area of investigation. NK cells can also be utilized in the context of hematopoietic stem cell transplantation to improve outcomes and reduce complications. Moreover, ongoing research is uncovering ways to modulate NK cell activity pharmacologically, opening avenues for the development of novel immunotherapies.

Our Solutions for Priming NK Cell Research

Expanded Human NK Cells, Frozen

• Enriched and expanded NK cells from human PBMCs
• Ideal for ADCC or NK cell cytotoxicity assays
• Can be further expanded
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NK Cell Expansion Kit

• Engineered K562 feeder cell system
• NK Cell Basal Medium
• Two to three-fold exponential (x10² – 10³) expansion of NK cells
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Recombinant Proteins

• Purified NK cell molecules and ligands for in vitro ligand binding assays
• Multiple labels and tags available
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Cell Lines

• Reporter cells for co-culture assays to screen for inhibitors or ADCC modulators
• NK molecule or ligand-expressing cell lines
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Assay Kits

• Biochemical and cell-based assay kits to screen for checkpoint inhibitors
• High throughput options available, including homogeneous assays in 384-well plates
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High-Titer Lentiviruses for Cell Engineering

• For expression of CARs, NK molecules or ligands
• CRISPR/Cas9 lentiviruses for knocking out NK-related molecules
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CAR-NK Reagents

• NK Viral Transduction Enhancer
• NK Cell Culture Cytokine Cocktail
• CAR NK Medium, Serum-Free
• Primary NK Transduction Kit

Antibodies and Bioactive Cytokines

• Neutralizing or agonistic antibodies targeting NK proteins and ligands. View Products
• Cytokines suitable for cell culture applications including IL-2, IL-8, IL-15, IL-18, IL-21 and more. View Products

Custom Product Development

Looking for custom products for your research project? We can help with that. Contact us or view our custom development options.

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