CRISPR Lentiviruses

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Knocking out the expression of a gene of interest is particularly valuable in target validation studies or to examine the biological function of the gene.

The CRISPR/Cas9 Lentiviruses are replication incompetent, VSV-G pseudotyped lentiviral particles that are ready to infect a wide range of mammalian cells including both primary and non-dividing cells. They are safe to use and require only a biosafety level 2 (BSL-2) facility.

These lentiviruses transduce the Streptococcus pyogenes Cas9 gene, along with 5 single-guide RNAs (sgRNAs) targeting the gene of interest.

They can be used to knock-down the gene of interest in target cells, or for the generation of stable knock-out cell lines following limited dilution.

CRISPR/Cas9 Kinase Knockout Lentivirus Library

The integrating CRISPR/Cas9 Kinase Knockout Lentivirus Library covers the known human kinome: 513 kinases and 106 pseudo-kinases, along with control sgRNAs. Individual kinases and custom kinase panels are also available.

Immunotherapy Targets

Integrating and non-integrating lentiviruses allow for the validation and characterization of new modalities targeting immune checkpoints (PD-1, PD-L1, CTLA4, TIGIT, and more).

CRISPR Services

Learn more about our knock-in and knock-out custom services.

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