In Vitro Toxicity Research Solutions
In vitro toxicity testing plays a critical role in drug development by enabling early and efficient identification of potential safety concerns, reducing reliance on animal testing, and supporting regulatory requirements for drug approval.
In vitro toxicity testing plays a critical role in drug development by enabling early and efficient identification of potential safety concerns, reducing reliance on animal testing, and supporting regulatory requirements for drug approval.
Early detection of toxicity
Before a drug can be tested in humans, it's essential to assess its safety profile. Now that U.S. Food and Drug Administration (FDA) no longer requires animal tests before human trials, assessing the potential toxicity of candidate drugs using in vitro systems is more critical than ever. In vitro testing allows researchers to identify potential toxic effects of drugs on various cell types or tissues without risking harm to humans or animals. When used early in the drug development process, it allows researchers to modify or discard compounds that demonstrate harmful effects before proceeding to more expensive and time-consuming animal testing or clinical trials. Furthermore, the ability to run automated high-throughput toxicity screens enables cost savings and efficiency. Additional testing using specific targets allows researchers to study the mechanisms underlying toxicity at the molecular level, guiding strategies on how to avoid or mitigate potential adverse effects.
Discovery tools for toxicity testing
Cell Lines & Primary Cells
- Cell lines constitutively expressing luciferase or eGFP for tracking/monitoring
- Cell lines expressing target proteins, including hERG (Kv11.1)
- PBMCs, T cells, NK cells
- View Products
iPSC-Derived Cardiomyocytes
- Human non-proliferative cardiomyocytes differentiated from iPSCs using the Wnt-modulation strategy
- Specialty media available
- View Products
Metabolic Enzyme Assay Kits
- Multiple formats including TR-FRET, chemiluminescent, fluorescence polarization, colorimetric and more
- View Products
- View Screening & Profiling Services
Purified Recombinant Metabolic Enzymes
- With or without tags, including Avi-tag, FLAG, His, Fc or biotin for binding assays, inhibition assays, or WB controls.
- Featuring COX1/2, ACC1/2, IDO1/2
- View Products