Demethylase Screening & Profiling

Histone demethylases are epigenetic regulators of chromatin structure and gene expression. Due to their deregulation or overexpression in cancer, and in cardiovascular and neurodegenerative diseases, they are important therapeutic targets. Additionally, DNA and RNA demethylation are also linked to tumorigenesis and are considered important targets for cancer therapy as well.

We offer an extensive selection of RNA, DNA, and histone demethylase target screening and profiling services. Our team of experts, using our in-house developed biochemical assay kits, can provide:

• Screening for activity and selectivity across our full panel or just select targets
• Determination of IC₅₀
• Project guidance and questions answered in a timely manner
• Delivery of detailed results promptly and on time

If follow-up studies are required, we can provide the same active proteins as the ones used in our assays.