Modulation of Gene Expression Without Changing the Genome

The field of epigenetics refers to the control or modulation of gene expression that produces a specific phenotype or trait without directly changing DNA sequences. Epigenetic control can occur by modifying DNA, RNA, or by modulating the proteins that bind to DNA, particularly histone proteins. Epigenetic modifications start early in embryonic development and continue as organisms age and are strongly influenced by environmental factors. The study of epigenetic mechanisms is critical to understanding drug mechanisms and cell biology spanning widely across research areas, from homeostasis to diseases including cancer, autoimmunity, neurodegeneration, addiction, and more.
We have developed an extensive portfolio of research products that are aimed at understanding mechanisms involved in epigenetics, including novel high purity active proteins and protein complexes, assay kits to measure enzyme function, and inhibitor/activator molecules.

Portfolio Highlights

500+ Active epigenetic proteins and protein complexes, including HiP™, high purity, low aggregation proteins.
Substrates, including histones, octamers, nucleosomes, and biotinylated versions.
200+ Epigenetic inhibitor screening assays, provided in an assortment of formats, including high-throughput homogeneous assays.
100+ Inhibitor/activator molecules to study epigenetic enzyme functions.

Biochemical Screening and Profiling Services

Save time by letting us screen your compounds of interest against our unique assay panels or determine IC50 values with our portfolio of 200+ assays, so you can focus on other facets of your research. We will provide a comprehensive report with both raw and analyzed data, graphs, detailed protocols, and other important information.
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