SARS-CoV-2 Coronavirus Variants
The COVID-19 pandemic, caused by the novel SARS-CoV-2
coronavirus, has ravaged the globe, infecting over 450 million people and causing over 6 million deaths as
of early 2022. The recent emergence of new SARS-CoV-2 variants is a severe concern, especially omicron and delta
variants, as many of these mutations occur within the Spike protein and appear to increase transmissibility and
infectivity. The graphics below outline key differences between different wordwide mutants and variants. For
more information on SARS-CoV-2 lineages, please visit cov-lineages.org.
Variant (Lineage)
Wild-Type
All Products
Location of ID
China
WHO Name
Wuhan-Hu-1 (reference strain)
Spike protein mutations:
No mutations
Nucleocapsid (N) protein mutations:
No mutations
Spike protein mutations:
T19I, LPPA24-27S, Δ69-70, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, P151S, R203K, G204R, S413R
Products
Spike protein mutations:
T19I, LPPA24-27S, Δ69-70, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, P151S, R203K, G204R, S413R
Products
Spike protein mutations:
T19I, LPPA24-27S, Δ69-70, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, P151S, R203K, G204R, S413R
Products
Spike protein mutations:
T19I, LPPA24-27S, Δ69-70, G142D, V213G, G339D, S371F,
S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V,
Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, P151S, R203K, G204R, S413R
Spike protein mutations:
T19I, LPPA24-27S, G142D, V213G, G339D, S371F, S373P, S375F,
T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R,
N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, R203K, G204R, S413R
Spike protein mutations:
A67V, Δ69-70, T95I, Δ142-144, Y145D, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, R203K, G204R
Spike protein mutations:
T19I, LPPA24-27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
Nucleocapsid (N) protein mutations:
P13L, Δ31-33, R203K, G204R, S413R
Spike protein mutations:
T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N
Nucleocapsid (N) protein mutations:
N/A
Products
Spike protein mutations:
Y145Δ, H146Δ, E484K, D614G
Nucleocapsid (N) protein mutations:
Unknown
Spike protein mutations:
T19R, G142D, Δ156/157, R158G, K417N, L452R, T478K, D614G, P681R, D950N
Nucleocapsid (N) protein mutations:
D63G, R203M, D377Y
Spike protein mutations:
T19R, G142D, Δ156/157, R158G, L452R, T478K, D614G, P681R, D950N
Nucleocapsid (N) protein mutations:
D63G, R203M, D377Y
Spike protein mutations:
G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
Nucleocapsid (N) protein mutations:
R203M, D377Y
Spike protein mutations:
L452R, E484Q, D614G, P681R
Nucleocapsid (N) protein mutations:
R203M, D377Y
Spike protein mutations:
W152C, L452R, D614G
Nucleocapsid (N) protein mutations:
N/A
Spike protein mutations:
L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I
Nucleocapsid (N) protein mutations:
P80R
Spike protein mutations:
L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, A701V
Nucleocapsid (N) protein mutations:
T205I
Spike protein mutations:
L18F, D80A, D215G, Δ242-244, R246I, K417N, E484K, N501Y, D614G, A701V
Nucleocapsid (N) protein mutations:
T205I
Products
Spike protein mutations:
ΔH69/V70, ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
Nucleocapsid (N) protein mutations:
D3L, R203K, G204R, S235F
