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B cell maturation antigen (BCMA), a cell surface protein primarily expressed by mature B cells and antibody-producing plasma cells, is an effective immunotherapy target for treating multiple myeloma and other B cell disorders.

BCMA, also known as TNFRSF17 belonging to the TNF receptor superfamily, binds to APRIL/TNFSF13 and BAFF/TNFSF13B/CD257 and regulates B cell development and survival, as well as maintaining plasma cell populations. BCMA can be cleaved by γ-secretase, resulting in a soluble form of BCMA, which is a potential biomarker for multiple myeloma, as well as being a source of interference for potential therapeutics. Targeting BCMA has become a focal point in the development of immunotherapies, including antibody-drug conjugates (ADCs), bispecific T cell engagers (BiTEs), and chimeric antigen receptor (CAR) T cell therapies, aiming to specifically eliminate pathogenic B cells. These innovative approaches may well improve outcomes for patients with various B cell malignancies or autoimmunity, offering new avenues for more effective and targeted treatments.

BCMA Diagram BPS Bioscience

A Suite of Critical Tools for BCMA Immunotherapy Research

Cell Lines & Primary Cells

BCMA Cell Lines & Primary Cells

Recombinant Proteins

BCMA Recombinant Proteins
  • Recombinant BCMA with functionalized IgG Fc and Avi-Tag
  • PE and Biotin conjugates available
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Antibodies & BiTEs

BCMA Antibodies & BiTEs
  • Biotin, FITC, and PE antibody conjugates available
  • Bispecific and tri-specific molecules
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High-Titer Lentiviruses

BCMA High-Titer Lentiviruses
  • For expression of anti-BCMA CARs on effectors or BCMA on target cells of interest
  • CRISPR/Cas9 LVs for knockout
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