Small molecule enzyme inhibitors and activators are compounds that can modulate the activity of enzymes. Enzyme inhibitors bind to enzymes and prevent them from catalyzing reactions, while enzyme activators enhance their catalytic activity. Small molecules have significant therapeutic potential, providing some pharmacological advantages over biologics and are used in treating diseases caused by overactive or underactive enzymes or targeting pathogen-specific enzymes. Enzyme inhibitors and activators remain an active area of research in drug discovery and development. BPS Bioscience provides known positive controls for inhibitors and activators to affect protein function or for use in our biochemical and cell-based assays.
Molecular model of SARS-CoV-2 3CL protease dimer (teal/blue) in complex with inhibitor GC376 based on PDB ID 7CBT.
