DNA Replication & Repair Screening & Profiling

DNA replication and repair are crucial processes for maintaining genetic integrity and ensuring the accurate transmission of genetic information necessary for cell division, growth, and development. Errors in replication can lead to mutations, resulting in genetic disorders and increased susceptibility to diseases like cancer. DNA repair mechanisms play a vital role in identifying and correcting damage to the DNA molecule caused by various internal and external factors, such as chemical agents, radiation, and replication errors. Without efficient repair mechanisms, DNA damage can accumulate, leading to genome instability and the potential for cell death or malignant transformation. Thus, the proper functioning of DNA replication and repair processes is essential for maintaining genome stability, cellular homeostasis, and overall organismal health. However, therapies are now targeting DNA repair as a mechanism to induce synthetic lethality in cancers, enabling new modalities to overcome cancers.