Custom Services Frequently Asked Questions

Development services: we develop custom recombinant proteins and new assays, generate cell lines overexpressing a target of interest or containing a reporter gene, and develop cells containing the CRISPR-mediated genetic modification(s) of your choice. In addition, we can assist you with the design and validation of a tailored chimeric antigen receptor (CAR) of interest, or with AAV (Adeno Associated Virus) or lentivirus development. Visit BPS Bioscience Services for more information.

Screening and Profiling:

• Biochemical Screening and profiling services: our full portfolio of >600 assays is available as a service: we perform screening, IC₅₀ determination, and comparisons of drug efficacy across protein families. Visit Screening and Profiling Services to learn more.
• Cell-based screening services: characterize or titrate your drug in one or several cell lines. Cellular studies provide a biological context, allowing for more informed decisions about which compounds to advance to development. Visit Immunotherapy Screening Services

Absolutely. Our team of scientists will communicate with you throughout the project's design to ensure that the results correspond to what you need.

Yes. Our assays are validated with an internal control using a commercially available inhibitor whenever available. When several compounds have been used in an assay (visit the assay page), you can choose between them. Some assays may not have a commercially available reference inhibitor.

Alternatively, you may request that we use a reference compound of your choice. Please send your reference compound to us together with your test compounds, indicating clearly which compound is your reference.

Please use the contact form at the bottom of the Contact Us page, where you can provide your contact information and details about your project.

Make sure to include which target protein(s) you wish to study, how many compounds you have to test, and whether you need a single concentration assay or a full IC₅₀.

Remember that if several reference compounds are available for an assay, you need to indicate which one(s) should be used as internal control(s). If you wish to use a different reference compound than the compound used by BPS, please send it to us together with your test compounds, indicating clearly which compound is your reference.

Alternatively:

• Contact your Sales representative (US) at [email protected]
• International customers (non-US) should contact their local distributor. For a list of International Distributors, visit Worldwide Distributors

Prior to shipping your compounds, please review our Compound Submission guidelines. Fill out a “Compound Submission Form” and include it with your compounds when shipping, in addition to sending it to the email address provided on the form.

Biochemical Assay Compound Submission Form

Cellular Assay Compound Submission Form

Remember that if several reference compounds are available for an assay, you need to indicate which one(s) should be used as internal control(s). If you wish to use a different reference compound than the compound used by BPS, please send it to us together with your test compounds, indicating clearly which compound is your reference.

Compound Preparation:

• Biochemical assays: Prepare at least 50 µl of compound solution, at a concentration that is 100-fold higher than the highest concentration to be tested if the diluent is DMSO (dimethyl sulfoxide).
• Cellular assays: Prepare at least 50 µl of compound solution, at a concentration that is 1000-fold higher than the desired final concentration if the diluent is DMSO.

As a rule, compounds in solution are preferred over powder form. Let us know is the diluent is DMSO or distilled water. We do accept dry compounds as long as their molecular weights are clearly indicated, to ensure accurate solutions are prepared. If sending your compounds in powder form, please send 1 to 3 mg, depending on the molecular weight of the compound. If we experience issues with compound solubility, unless informed otherwise, we will take the following steps to solubilize the compound:

• Further dilution (if possible)
• Sonication
• Heat at 50°C

BPS will store compounds for a maximum of 6 months after receipt.

Mail your compounds to:

BPS Bioscience
ATTN: Compound Submissions
6405 Mira Mesa Blvd., Suite 100
San Diego, CA 92121
Phone: 858-202-1401

Once the package has been shipped, notify us of the tracking number, so we can monitor the shipment and ensure your compounds arrive safely.

When a project has been completed, BPS Bioscience will provide you with an extensive report containing raw and analyzed data, graphs, and detailed protocols. Testing typically includes internal controls for inhibition. This report will be sent to you directly.

Yes. Our services correspond to existing assays, which can be viewed on our website. Open the datasheet corresponding to the assay you are interested in. All our assay kits are provided with detailed protocols and validation data, available from the datasheet.