Protein phosphorylation regulates almost all aspects of cell biology including cellular division, metabolism, signal transduction, and much more, a discovery that earned E. Fisher and E. Krebs the Nobel prize in Physiology in 1992.
Kinases catalyze the transfer of a phosphate group from ATP to another molecule. There are over 500 kinases encoded by the human genome controlling approximately 50% of all cellular functions. Kinases are divided into distinct families based upon their substrates: lipid, nucleotide, carbohydrate, and protein.
Protein Kinases are further classified based on the amino acid(s) they phosphorylate, such as tyrosine, serine/threonine, or histidine. A few protein kinases are dual kinase that phosphorylate their substrate on both tyrosine and serine/threonine residues.
Kinase Protein Products by Family
Kinase Inhibitor Screening Assay Kits
Screening for kinase inhibitors requires robust, consistent assays that deliver quality data to advance the best candidates. Our in-house developed assay kits provide large signal-to-noise readings, providing optimal accuracy in determining inhibitory concentrations. The assay formats are also optimized for high-throughput screening using homogeneous no-wash assays. Discover our vast selection of options.
Purified, tagged, active kinases and kinase complexes. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays.
Cell lines overexpressing tyrosine kinase receptors are available to study in a biological system or may be generated upon request.
Off-the shelf assay kits to measure kinase activity, and homogeneous JH2-domain assays to screen compounds against JAK family pseudo-kinase domains.
PROTAC optimization: homogeneous assays to assess the adaptor function of molecular degraders aimed at a kinase of interest.
Substrates and Inhibitors, used to measure kinase activity and to study function.
Biochemical Screening and Profiling Services
Accelerate your research using our screening services: single dose screening or IC50 determination across kinase families. Results delivered with a comprehensive report containing detailed protocols, raw and analyzed data, and other important information. Learn more.