Coronavirus Lentiviruses

To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into host cells. BPS also offers the control (bald) lentivirus without Spike protein as well as ACE2 lentivirus to transduce cells for transient expression or to create stable cell lines as targets for the Spike pseudovirion.

Catalog #
  1. ACE2 Lentivirus
    6 citations
    500 µl x 2
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