TGF-β Superfamily Research Products

TGF-β Superfamily Research Products Landing Page BPS Bioscience

The TGF-β superfamily is a large group of cytokines encompassing over 30 members that play crucial roles in regulating cellular processes such as proliferation, differentiation, apoptosis, and migration.

The TGF-β (Transforming Growth Factor-beta) superfamily consists of TGF-betas, bone morphogenetic proteins (BMPs), activins, inhibins, left-right determination factors, as well as several divergent members. These proteins are integral to embryonic development, tissue homeostasis, and immune responses. They signal through heterodimeric Type I and Type II kinase receptors that initiate signaling via SMAD proteins. Dysregulation of TGF-β signaling is implicated in various diseases, including cancer, fibrosis, and autoimmune disorders. Due to their significant biological functions, TGF-β superfamily members have considerable therapeutic potential, with ongoing research and development of targeted therapies aimed at modulating their activity to treat conditions like cancer, fibrotic diseases, and bone-related disorders.

TGF-β Superfamily Proteins Diagram

Solutions that Enable TGF-β Research

We develop innovative research tools for study and analysis of TGF-β superfamily proteins and their receptors, including novel products such as our TGFβ/Activin A-Responsive Luciferase Reporter HEK293 Cell Line. Find the right tools for your research below.

Recombinant Proteins

TGF-b Recombinant Proteins
  • TGF-β proteins, TGF-β Receptors, ALK2 (ACVR1) mutants
  • Activin Blocker
  • Fc fusion and Biotin conjugates available
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Biochemical Assay Kits

TGF-bBiochemical Assay Kits
  • Receptor/ligand binding kits for inhibitor screening
  • Receptor kinase activity kits for small molecule inhibitor discovery
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High-Titer Lentiviruses

TGF-bHigh-Titer Lentiviruses
  • Lentiviruses for reporter gene delivery
  • TGFBR2 CRISPR/Cas9 for cellular knockout
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