TGF-β Superfamily Research Products

The TGF-β superfamily is a large group of cytokines encompassing over 30 members that play crucial roles in regulating cellular processes such as proliferation, differentiation, apoptosis, and migration.

The TGF-β (Transforming Growth Factor-beta) superfamily consists of TGF-betas, bone morphogenetic proteins (BMPs), activins, inhibins, left-right determination factors, as well as several divergent members. These proteins are integral to embryonic development, tissue homeostasis, and immune responses. They signal through heterodimeric Type I and Type II kinase receptors that initiate signaling via SMAD proteins. Dysregulation of TGF-β signaling is implicated in various diseases, including cancer, fibrosis, and autoimmune disorders. Due to their significant biological functions, TGF-β superfamily members have considerable therapeutic potential, with ongoing research and development of targeted therapies aimed at modulating their activity to treat conditions like cancer, fibrotic diseases, and bone-related disorders.