ADC and Antibody-Based Cancer Therapies

Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers.

Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers.

Monoclonal antibodies, which are laboratory-produced molecules that bind to a specific target (protein, carbohydrate, lipid, or small molecule), have revolutionized life science research and medicine. Many therapeutic drugs in use today are engineered monoclonal antibodies targeting a diverse range of diseases, including autoimmune disorders such as arthritis, psoriasis, and inflammatory bowel disease, and cancers such as lymphomas, breast cancer, and many others. Depending on the target, the antibody structure, and the disease, antibodies and antibody-derived molecules can be used for a wide variety of applications, summarized below.

An ever-increasing diversity of antibody-based cancer therapies are now in development with many demonstrating remarkable success in various malignancies. Antibody-drug conjugates (ADCs) and multi-specific T cell or NK cell engagers are two emerging therapeutic modalities. As research and development in this field continue to advance, antibody-based cancer therapies hold great promise for the future, offering new hope for patients and contributing to the ongoing evolution of personalized and precise cancer treatment strategies.

Innovative solutions for ADC and antibody-based therapy discovery

Cell Lines for ADC Targeting

• Cell lines with high, medium, or low target antigen expression, including CD19, HER2, BCMA, DLL4, Nectin-4, and many more.
• Cell lines constitutively expressing luciferase or eGFP.
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Antibodies & Multi-specific Molecules

• Find conventional antibodies against ADC targets, positive control bispecific and trispecific antibodies and T cell engagers for your research.
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Sortase-Mediated Antibody Labeling Kit

• Enables site-specific antibody conjugation for the development of ADCs.
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Purified Recombinant Proteins

• With or without tags, including Avi-tag, FLAG, His, Fc or biotin for binding assays or WB controls.
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ADC Linkers & Payloads

• Cleavable and non-cleavable linkers, plus common payloads for ADCs.
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Custom Services

• Protein Binding Studies/BLI
• Bispecific Ab and BiTE Custom Development
• Cell Line Development
• Custom Protein Expression

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