Immunotherapy Screening

BPS Bioscience offers rapid and dependable Immunotherapy Screening Services of small molecules, peptides, and antibodies against requested targets by IC50 determination. Our team of experts along with our broad services portfolio make it easy to:

  • Screen for inhibitors/targets
  • Select from IC50 determination and single point concentrations
  • Receive data within days of compound submission
  • Perform follow-up studies using the same soluble receptors manufactured in-house
  • Get questions answered or project guidance in a time-efficient manner

Biochemical Assays

 

Cell-Based Assays

  • A2AR
  • BTLA
  • CD40:CD40L
  • CD27
  • CD137:CD137L
  • CTLA4
  • GITR:GITRL
 

Background:

Immunotherapy is a new and innovative way to treat disease. Rather than use localized and ineffective treatment methods, immunotherapy has emerged as an all-encompassing way to help the body effectively fight against disease. The immune system protects us against viruses, bacteria, and many diseases. But unfortunately, sometimes the immune system fails to recognize pathogens as a threat. The result of this immune system failure can be disastrous as cancer cells spread throughout the body and disease wreaks havoc on the individual.

The power of immunotherapy comes from its ability to specifically tailor immune responses to target dangerous cells. These therapeutic methods can alter how the immune system perceives diseases in order to enhance immune responses. For example, cancerous cells often have mechanisms in place to avoid immune system detection. As a result, the immune system does not recognize the cancer as a threat so the tumorous cells proliferate and spread throughout the body.

Traditional cancer treatment methods like chemotherapy treats the patient with toxins as a way to kill the cancerous cells. But this approach often is too general and broad, resulting in the death of healthy cells as well. 

Immunotherapy achieves high levels of specificity through the use of small inhibitors, activators, antibodies, and through targeting unique receptors. State of the art immunotherapy technology is revolutionizing drug development and forever altering how we treat disease.