PARG Screening & Profiling

PARG (Poly(ADP-ribose) glycohydrolase) is a protein that plays a crucial role in DNA repair processes, including base excision repair and single-strand break repair. Its function involves removing poly(ADP-ribose) (PAR) from proteins that have been modified by PAR polymerases (PARPs), which enables DNA repair. Dysregulation of PARG activity has been implicated in various diseases, including cancer. Targeting PARG for therapy has gained attention as a potential strategy for sensitizing cancer cells to DNA damage-inducing agents. Inhibition of PARG activity has been shown to increase the accumulation of PAR on proteins, that can interfere with DNA repair mechanisms, ultimately leading to cell death. Therefore, developing PARG inhibitors as therapeutic agents has emerged as a promising approach for cancer treatment, particularly in combination with DNA damage-inducing agents such as radiation and chemotherapy.