PARG Screening & Profiling

PARG (Poly(ADP-ribose) glycohydrolase) is a protein that plays a crucial role in DNA repair processes, including base excision repair and single-strand break repair. Its function involves removing poly(ADP-ribose) (PAR) from proteins that have been modified by PAR polymerases (PARPs), which enables DNA repair. Dysregulation of PARG activity has been implicated in various diseases, including cancer. Targeting PARG for therapy has gained attention as a potential strategy for sensitizing cancer cells to DNA damage-inducing agents. Inhibition of PARG activity has been shown to increase the accumulation of PAR on proteins, that can interfere with DNA repair mechanisms, ultimately leading to cell death. Therefore, developing PARG inhibitors as therapeutic agents has emerged as a promising approach for cancer treatment, particularly in combination with DNA damage-inducing agents such as radiation and chemotherapy.

We offer rapid and dependable screening and profiling services for PARG inhibitors. Our team of experts, using our in-house developed biochemical assay kits, can provide:

  • Screening for active compounds
  • Determination of IC50
  • Project guidance and questions answered in a timely manner
  • Delivery of detailed results promptly and on time

Learn more about the process and deliverables.

Principle of the Assay & Inhibitor Data

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Note: Not all targets will have a commercially available reference control. Please inquire with our team if you need to furnish your own controls for specific targets.