RediSolution™ (+)-JQ1

Catalog #

27403

$85 *

Size: 1 mg

Qty

Bulk/Custom

*US Pricing only. For international pricing, please contact your local distributor.

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Description

(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.

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Synonyms

BET inhibitor, Bromodomain inhibitor

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC

Supplied As

10 mM solution in anhydrous DMSO

Format

DMSO solution

Formula

C₂₃H₂₅ClN₄O₂S

457.0 Da

Biological Activity

(+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.

CAS Registry #

1268524-70-4

References

Filippakopoulos P., et al. Nature. 468(7327):1067-73 (2011).

Application Reference:
1. BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen (2014)
2. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology (2014)