(+)-JQ1

Catalog #

27402

$95 *

Size: 5 mg

Qty

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Description

(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.

This product has been cited 23 times.

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Synonyms

BET inhibitor, Bromodomain inhibitor

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Product Data Gallery

Product Info

Storage and Usage

Citations23

Purity

≥95% by HPLC

Format

A crystalline solid.

Formula

C₂₃H₂₅ClN₄O₂S

457.0 Da

Solubility

Soluble in DMSO or ethanol; insoluble in water.

Biological Activity

(+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.

CAS Registry #

1268524-70-4

References

Filippakopoulos, P., et al., Nature. 468(7327):1067-73 (2011).