Anti-CD20 Agonist Antibody

Catalog #: 71209
Size: 100 µg
$300
Species: Human
Host Species: Freestyle 293 cells
MW: 150 kDa
Tag(s): none
Clonality: Monoclonal (human)
Isotype: IgG1κ
Description:

Anti-CD20 is a recombinant monoclonal antibody which features the constant region of the human IgG1 isotype and the variable region of rituximab. It binds to human CD20 extracellular region a.a 142- 184, where it acts asan agonist of the CD20 protein. Itis expressed in a 293 freestyle cell expression system and purified using protein A chromatography. MW = 150 kDa.

Synonym(s):
rituximab
Endotoxin Level:

<1 EU/ µg

Assay Conditions:
WIL2-S cells were treated with anti-CD20 + 10% rabbit complement. Cell viability was determined using AlamarBlue® Indicator.
Formulation:
10mM PBS pH 7.4, 138mM NaCl, and 2.8mM KCl.
Species Reactivity:
Human
Purification:
Protein A affinity chromatography from HEK293 supernatants.
Immunogen:
Human CD20 extracellular region
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at -80°C.

Application(s):
Useful for the detection of CD20 and binding to B cells or other cells expressing CD20 on their surface.
Reference(s):

1. Ganjoo KN, et al., Leuk Lymphoma. 2014 April 9.

2. Siegal T., J Clin Neurosci. 2014 April;21(5):709-715.

Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Immunotherapy
Product Type:
Antibody
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Product Datasheets

71209.pdf