Anti-PD-1 Neutralizing Antibody

Catalog #
71120
$365 *
Size: 100 µg
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Description

Neutralizing recombinant murine/human chimeric antibody recognizing the PD-L1/PD-L2 binding region of human PD-1. This antibody does not cross-react with mouse PD-1, but does cross-react with monkey (M. fascicularis) PD-1. It has not been tested with other species.

This product has been cited 16 times.

Synonyms
Programmed Cell Death 1, CD279, PDCD1, SLEB2
Product Info
Storage and Usage
Citations16
Species
Human/Mouse
Isotype
IgG1
Clonality
Monoclonal
Host Species/Expression System
Freestyle 293 cells
Purification
Protein A affinity chromatography from HEK293 supernatants.
Format
Aqueous buffer solution
Formulation
8 mM phosphate pH7.4 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Immunogen
PD-L1/L2 binding region of human PD-1
MW
50 and 25 kDa for the heavy and light chains, respectively (150 kDa).
Specific Activity
IC50 = 1.2 nM using the PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit (BPS Cat. #72005). IC50 = 4.7 nM using the PD-1[Biotinylated]:PD-L2 Inhibitor Screening Assay Kit (BPS Cat. #72006).
UniProt #
Q15116
Tag(s)
none
References

1. Shinohara, T., et al., Genomics. 1994 Oct;23(3):704-6.

2. James, E.S., et al., Genes Immun. 2005 Aug;6(5):430-7.