ACE2, His-Tag Recombinant

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Catalog #

11003

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Description

Recombinant human ACE2 (angiotensin converting enzyme 2), encompassing amino acids 18-740. The construct contains a C-terminal His-Tag (10xHis). The protein was affinity purified.

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Synonyms

ACE2, ACEH, angiotensin I converting enzyme 2, sars, sars protease

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Product Data Gallery

4-20% SDS-Page Coomassie Staining

ACE2 Activity

2019-nCoV Spike Protein/Human ACE2, His-tag BLI

2019-nCoV Spike Protein/Human ACE2, His-tag DELFIA

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

HEK293 cells

Purity

≥90%

Supplied As

Aqueous buffer solution.

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 20% glycerol

85 kDa + glycans

Amino Acids

18-740

Glycosylation

This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Genbank #

NM_021804

UniProt #

Q9BYF1

Tag(s)

C-terminal His-tag

References

1. Oudit, G.Y., et al., Trends in Cardio. Med. 2003 Apr;13(3):93-101.
2. Donoghue, M., et al., Circulation Research. 2002 Sep;87:e1-e9

Storage/Stability

At least 6 months at -80°C.

Assay Conditions

Assay was done according to ACE2 Inhibitor Screening Assay Kit (BPS Bioscience #79923) with ACE2 titrated from 20 ng/rxn to 0.31 ng/rxn.

Instructions for Use

Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.

Applications

As an exopeptidase, ACE2 is useful for the study of enzyme kinetics and to screen for inhibitors. As a cell receptor for coronaviruses infection, including 2019-nCoV, ACE2 is useful for the study of protein-protein interactions. Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Shipping Temperature

-80°C

Warnings

Avoid freeze/thaw cycles.

Scientific Category

Protease, Coronavirus, COVID-19

Regulatory Status

Research Use Only

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ACE2, His-Tag Recombinant

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