ACE2 Inhibitor Screening Assay Kit
The ACE2 Inhibitor Screening Assay Kit is a 96-well homogeneous fluorogenic assay designed to measure the exopeptidase activity of ACE2 (Angiotensin converting enzyme 2) for screening and profiling applications. The ACE2 kit contains enough purified ACE2 (amino acids 18-740), ACE2 substrate, and ACE2 buffer for 100 reactions.
Figure 1: Illustration of the assay principle.
Cleavage of the peptide by ACE2 releases L-phenylalanine, which is measured by a two-step reaction and detection of a fluorogenic product. The fluorescence signal increases in proportion to ACE2 activity.
Note: For an assay with higher sensitivity, please refer to Fluoro-Verse™ ACE2 Inhibitor Assay Kit (BPS Bioscience #78847).
This product has been cited 24 times.
| Catalog # | Name | Amount | Storage |
| 11003 | ACE2, His-Tag* | 2 µg | -80°C |
| ACE2 Fluorogenic Substrate | 2.5 ml | -80°C | |
| ACE2 Buffer | 3 ml | -20°C | |
| 79685 | 96-well black microplate | 1 | Room Temp |
* The concentration of protein is lot-specific and will be indicated on the tube containing the protein.
Angiotensin converting enzyme 2 (ACE2) is an exopeptidase that catalyzes the conversion of angiotensin II to angiotensin 1-7 and L-phenylalanine. Angiotensin II is part of the classical renin angiotensin system (RAS), a hormone system that regulates fluid balance, blood pressure, and maintains vascular tone. ACE2 plays a role in lowering blood pressure and in cardiovascular health and therefore, is an attractive therapeutic target. ACE2 is also the receptor for the human respiratory coronaviruses NL63, SARS (SARS-CoV) and 2019-nCoV/SARS-CoV-2.
Jackson C., et al., 2022 Nature 23: 3-20
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