Wortmannin (Discontinued)
Catalog #
27031
$120
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Description
Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase.
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Synonyms
KY 12420
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥99%
Format
White to off-white solid.
Formula
C23H24O8
MW
428.43 Da
Solubility
Soluble in DMSO or ethanol; very poor solubility in water; maximum solubility in plain water estimated to be about 10-50µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
CAS Registry #
19545-26-7
References
1. Wymann, M.P. et al.; (1996). Mol. Cell. Biol. 16, 1722.
2. M. Ui, et al. (1995). TIBS 20, 303.
3. Arcaro, A. and Wyman, M.P. (1993). Biochem. J. 296, 297.
2. M. Ui, et al. (1995). TIBS 20, 303.
3. Arcaro, A. and Wyman, M.P. (1993). Biochem. J. 296, 297.