PI3 kinase (p110α/p85α) Recombinant
Catalog #
40621
$415
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Description
Complex of human PI3 kinase (phosphatidylinositol-4,5-bisphosphate 3-kinase) catalytic subunit p110α (also known as PIK3CA) and regulatory subunit p85α (also known as PIK3R1).
Recombinant human p110α, encompassing amino acids 2-1068 (end), contains an N-terminal GST-tag. Recombinant human p85α, full length encompassing amino acids 1-724 (end), does not contain a tag. The proteins were co-expressed in Sf9 insect cells and formed a complex which was affinity purified.
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Synonyms
PIK3CA, p110alpha, Phosphoinositide-3-Kinase, Catalytic, Alpha, PIK3R1, Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), GRB1, p85alpha
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
PI3K (p110α/p85α) Activity
Product Info
Storage and Usage
Citations
Species
Human
Construct
PI3 kinase (p110α (GST-2-1068(end)) / p85α (1-724(end)))
Host Species/Expression System
Sf9
Purity
≥90%
Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, pH 8.0, 69 mM NaCl, 1.3 mM KCl, 0.03% Tween-20, 50% glycerol, and 3 mM DTT
MW
p110α: 151 kDa; p85α: 84 kDa
Amino Acids
p110α: 2-1068(end); p85α: 1-724(end)
Specific Activity
880 pmol/min/μg
Genbank #
p110α: NM_006218; p85α: NM_181523
UniProt #
p110α: P42336; p85α: P27986
References
1. Vogt, PK et al., Virology. 344(1):131-(2006)
2. Bader, AG et al., Nat Rev Cancer. Dec 5(12):921-9 (2005)
2. Bader, AG et al., Nat Rev Cancer. Dec 5(12):921-9 (2005)
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