GDC-0941
Catalog #
27000
$160
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Description
GDC-0941, also known as Pictilisib, is a phosphatidylinositol 3-kinase (PI3K) inhibitor
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Synonyms
GDC-0941, Pictilisib
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥99% by HPLC.
Format
Solid
Formula
C23H27N7O3S2
MW
513.6 Da
Solubility
Soluble in DMSO at 66 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µg
Biological Activity
GDC-0941 against p110a IC50=0.003µM. The IC50 for inhibiting cell proliferation in PC3 (prostate cancer) or U87MG (glioma) cells is 0.28 µM and 0.95 µM, respectively.
CAS Registry #
957054-30-7
References
1. Folkes, A.J. et al. J. Med. Chem. 51: 5522-5532 (2008)
2. Yao, E. et al. Clin. Cancer Res. 15: 4147-4156 (2009)
2. Yao, E. et al. Clin. Cancer Res. 15: 4147-4156 (2009)
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