Wortmannin (Discontinued)

Catalog #

27031

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Description

Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase.

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Synonyms

KY 12420

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

White to off-white solid.

Formula

C₂₃H₂₄O₈

428.43 Da

Solubility

Soluble in DMSO or ethanol; very poor solubility in water; maximum solubility in plain water estimated to be about 10-50µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

CAS Registry #

19545-26-7

References

1. Wymann, M.P. et al.; (1996). Mol. Cell. Biol. 16, 1722.
2. M. Ui, et al. (1995). TIBS 20, 303.
3. Arcaro, A. and Wyman, M.P. (1993). Biochem. J. 296, 297.

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Wortmannin (Discontinued)

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