Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
27315 5 mg Ac-DEVD-CMK
$330
27700 10 mg Aclacinomycin A
$295
70019 20 µg Activated Protein C (PROC), His-tag
$425
27300 1 mg Aliskiren Hydrochloride
$565
27736-2 10 mg AT13387
$240
71656 96 reactions BACE1 FRET Assay Kit
$530
71657 100 μg BACE1, His-Tag (Human)
$325
27054 5 mg BMS-790052
$270
27028 10 mg Bortezomib
$150
27042 10 mg Brefeldin A
$165
27055 10 mg Camostat Mesilate (FOY-305)
$130
80700 96 reactions Caspase-3 Homogeneous Assay Kit
$285
80703 96 reactions Caspase-6 Homogeneous Assay Kit
$365
80701 96 reactions Caspase-7 Homogeneous Assay Kit
$365
80704 96 reactions Caspase-8 Homogeneous Assay Kit
$365
80500

10 µg
50 µg

Caspase3, His-tag
Starting at:
$260
80113

10 µg
50 µg

Caspase6, His-tag
Starting at:
$260
70000

10 µg
50 µg

Caspase7, His-tag
Starting at:
$260
80114

10 µg
50 µg

Caspase8, His-tag
Starting at:
$260
80115 50 µg Caspase9, His-tag
$365
79590 96 reactions Cathepsin B Inhibitor Screening Assay Kit
$440
80001 10 µg Cathepsin B, His-tag
$385
80003 50 µg Cathepsin F, His-tag
$375
79591 96 reactions Cathepsin L Inhibitor Screening Assay Kit
$440
80005 10 µg Cathepsin L, His-tag
$375

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