Protease(s)

 

Protease is the name given to a class of enzymes that catalyze protein catabolism by hydrolysis of the peptide bonds linking amino acids together. Proteases have evolved to perform these reactions by numerous different mechanisms and are found in animals, plants, bacteria, archaea, and viruses, highlighting the important role that they play in all forms of life on Earth. Proteases are involved in protein processing, regulation of protein function, apoptosis, viral pathogenesis, digestion, photosynthesis, and numerous other vital processes.

More recently, various industries have begun to take advantage of proteases as an active ingredient in specific products or as a research tool. For example, laundry detergents contain proteases to help break down stains; proteases are often added to bread during the baking process to help soften the final product; and the biotech industry takes advantage of highly specific proteases, such as TEV protease and thrombin, to cleave fusion proteins.

Proteases also offer a valuable target in many therapeutic settings, including Alzheimer’s, cancer, and viral infection. In fact, one of the most widely-used classes of anti-viral therapeutics is protease inhibitors, which are used to treat both HIV and HCV infections.

BPS offers a wide selection of purified proteases, assay kits, fluorogenic substrates, and inhibitors/activators to reach all your research needs. In addition, we also offer protease screening and profiling services if you prefer to take advantage of our screening experience and expertise in this area.

References:

1. Overall, C.M. & Kleifeld, O., Nat. Rev. Canc. 2006; 6: 227-239.
2. Turk, B., Nat. Rev. Drug Disc. 2006; 5: 785-799.
3. Anderson, J. et al., Handbook of Experimental Pharmacology. 2009; 189: 85-110.

 

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Catalog#SizeProduct NamePrice
80203 96 reactions DPP3 Assay Kit
$575
80204 96 reactions DPP4 Assay Kit
$425
80207 96 reactions DPP7 Assay Kit
$475
80208 96 reactions DPP8 Assay Kit
$475
80209 96 reactions DPP9 Assay Kit
$575
80210 96 reactions FAP Assay Kit
$950
80106 96 reactions POP Assay Kit
$600
80211 96 reactions Renin Assay Kit
$315
27315 5 mg Ac-DEVD-CMK
$320
27700 10 mg Aclacinomycin A
$155
70019 20 µg Activated Protein C (PROC), His-tag
$415
27300 1 mg Aliskiren Hydrochloride
$430
27736-1 5 mg AT13387
$230
27736-2 10 mg AT13387
$295
71657 100 μg BACE1, His-Tag (Human)
$315
27054 5 mg BMS-790052
$180
27028 5 mg Bortezomib
$145
27042 10 mg Brefeldin A
$160
27055 10 mg Camostat Mesilate (FOY-305)
$55
80700 96 reactions Caspase-3 Homogeneous Assay Kit
$275
80703 96 reactions Caspase-6 Homogeneous Assay Kit
$355
80701 96 reactions Caspase-7 Homogeneous Assay Kit
$355
80704 96 reactions Caspase-8 Homogeneous Assay Kit
$355
80500 50 µg Caspase3, His-tag
$425
80113 50 µg Caspase6, His-tag
$435

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