Ubiquitination

Ubiquitin is an 8.5 kDa protein that is expressed in almost all tissues, hence the name. Ubiquitination is a post-translational modification in which one or more ubiquitin proteins is added to a substrate protein by a reaction that is carried out in three main steps; activation, conjugation, and ligation. Addition requires the sequential action of 3 enzymes, ubiquitin activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Ubiquitination was originally described as the process that labels proteins for degradation by the proteasome, but was later found to have a number of distinct functions such as altered protein localization, modulation of protein-protein interaction, and activation or inactivation of target proteins. In addition to the highly studied proteosomal degradation pathway, ubiquitin modifications have been linked to the regulation of a number of other important cellular processes, including inflammation, response to stress or viral infections, DNA repair, and stem cell differentiation.

Many proteins regulated by ubiquitin modification control cellular processes that are essential for tumorigenesis and tumor growth, including cell cycle progression, apoptosis, and receptor trafficking and down-regulation. Recent years have seen significant progress in our understanding of the molecular basis of ubiquitin modifications in cancer progression and it has therefore become an attractive drug target.

BPS provides a number of active ubiquitin enzymes in addition to inhibitors and activators to give researchers the tools necessary to continue to advance our understanding of this important target.

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Catalog#SizeProduct NamePrice
27226 1 mg (R) - MG132
$105
27713 0.5 ml 1,10-Phenanthroline, Monohydrate
$80
80394 50 µg A20, FLAG-tag (Sf9-derived)
$425
80408 50 µg A20, His tag, FLAG-tag (Sf9-derived)
$425
80393 100 µg A20, His-tag (E. coli-derived)
$415
81081 25 µg AMSH Core Domain, His-tag
$355
81080 25 µg AMSH, His-tag
$355
80399 250 µg Ataxin3 (MJD1, SCA3), His-tag
$280
81082 25 µg Ataxin3-Like, His-tag
$355
27701-2 25 mg b-AP15 (NSC-687852)
$250
27701-1 5 mg b-AP15 (NSC-687852)
$90
81083 25 µg Bap1, His-tag
$205
81050 25 µg CARP2, SUMO-His-tags
$365
80413 50 µg CBL-B (Y363F), His-tag, Biotin-labeled (Human)
$355
80415 100 µg CBL-B, GST-Tag (Human)
$295
80414 100 µg CBL-B, His-Avi-Tag
$295
80412 50 µg CBL-B, His-tag, Biotin-labeled (Human)
$355
27702-1 10 mg Celastrol
$140
27702-2 50 mg Celastrol
$430
27224 50 µg Clasto-lactacystin β-lactone
$115
80409 20 µg CUL3/Rbx1, GST-tag
$360
27703-1 10 mg DBeQ
$155
81084 25 µg Den1, GST-tag
$205
81051 25 µg Hrd1, SUMO-His-tags
$265
27227 10 mg IU1
$115

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