Bap1, His-tag Recombinant

Catalog #

81083

$315 *

Size: 25 µg

Qty

Bulk/Custom

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Description

BAP1 is a deubiquitinase that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. It acts as a regulator of cell growth.

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Synonyms

BRCA1-associated protein 1, Cerebral protein 6, DKFZp686N04275, FLJ35406, FLJ37180, HUCEP-13, hucep-6, KIAA0272, Ubiquitin carboxyl-terminal hydrolase BAP1

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Product Data Gallery

10-20% SDS-PAGE Coomassie Staining (Representative data only; data may vary by lot.)

BAP1 Activity (Representative data only; data may vary by lot.)

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥85% by SDS-PAGE

Format

Aqueous buffer solution

82 kDa

UniProt #

Q92560

Tag(s)

His-tag

Background

BAP1 plays a critical role in regulating various cellular processes, including DNA repair, cell cycle control, and gene expression. It is particularly known for its involvement in maintaining genomic stability by deubiquitinating histones and other proteins involved in chromatin remodeling. Mutations or loss of BAP1 function have been associated with a higher risk of developing certain cancers, including uveal melanoma and mesothelioma, underscoring its significance as a guardian of genome integrity.

References

David E. Jensen and Frank J. Rauscher III. BAP1, a Candidate Tumor Suppressor Protein that Interacts with BRCA1. Ann N Y Acad Sci. 1999. 886: p191-4.

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Datasheets/Protocols

81083 Lot 240418

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