(R) - MG132

Catalog #

27226

$130 *

Size: 1 mg

Qty

Bulk/Custom

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Description

(R)-MG132 is a potent, cell permeable and reversible inhibitor of proteasomes. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. In comparison to (S)-MG132, the (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities.

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Synonyms

MG132

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Product Info

Storage and Usage

Citations

Purity

≥97% by HPLC

Format

A crystalline solid.

Formula

C₂₆H₄₁N₃O₅

475.6 Da

Solubility

Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in these solvents is approximately 25 mg/ml. Do not store aqueous solutions for more than one day.

Biological Activity

(R)-MG132 inhibits ChTL, TL and PGPH with IC50 values of 0.22 µM, 34.4 µM, and 2.95 µM, respectively.

CAS Registry #

1211877-36-9

References

1. Lee, D.H., et al., Trends Cell Biol. 1998;8:397-403
2. Elliot, P.J., et al., J. Mol. Med. 2003;81:235-245
3. Mroczkiewicz, M., et al., J. Med. Chem. 2010;53:1509-1518.

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(R) - MG132

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