Mouse JNK1, GST-tag Recombinant
Catalog #
40071
$410
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Description
Mouse JNK1 (GenBank Accession No. NM_016700), full length with N-terminal GST-tag, MW=71 kDa, expressed in a Baculovirus infected Sf9 cell expression system. The mouse amino acid sequence of JNK1 is identical to the one of human JNK1.
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Synonyms
JNK, JNK1, PRKM8, SAPK1, JNK1A2, JNK21B1/2, JNK-1
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Product Data Gallery
10% SDS-PAGE Coomassie Staining
Specific Activity
Product Info
Storage and Usage
Citations
Species
Mouse
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
71 kDa
Amino Acids
full length
Specific Activity
124 U/mg.
Unit Definition
One unit is defined as the amount of enzyme that will phosphorylate 1 nmol of 0.5 mg/ml ATF2 substrate per minute at pH 7.4 and 30°C.
Genbank #
NM_016700
Background
JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.
References
1. Derijard, B. et al. Cell. 1994 Mar 25,76(6):1025-37.
2. Kolodziejczyk, S M. et al. Curr Biol. 2001 Aug 21,11(16):1278-82.
2. Kolodziejczyk, S M. et al. Curr Biol. 2001 Aug 21,11(16):1278-82.
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