SP600125

Catalog #

27023

$130 *

Size: 50 mg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures.

●

Synonyms

Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone, Anthrapyrazolone, JNK Inhibitor II, JNK-1, JNK-2, JNK-3

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

Dark yellow solid

Formula

C₁₄H₈N₂O

220.2 Da

Solubility

Prepare initial stock solutions in DMSO (soluble at 65 mg/ml) for in vitro use; solubility in ethanol or water is low.

CAS Registry #

129-56-6

References

1. Bennett, B.L., et al. Proc. Natl. Acad. Sci. USA 98: 13681-13686 (2001).
2. Han, Z., et al. J. Clin. Invest. 108: 73-81 (2001).

Skip to the end of the images gallery

Skip to the beginning of the images gallery

SP600125

PRODUCTS

SERVICES

RESOURCES

COMPANY