Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

Items 26 to 50 of 151 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Catalog#SizeProduct NamePrice
32600 384 reactions BAZ2B Inhibitor Screening Assay Kit
$510
31113 100 µg BAZ2B, His-tag
$305
33000 0.5 ml @ 20 µM BET Bromodomain Ligand
$450
32632 384 reactions BPTF/FALZ TR-FRET Assay Kit
$1,025
32521 384 reactions BRD1 Inhibitor Screening Assay Kit
$510
32625 384 reactions BRD1 TR-FRET Assay Kit
$1,025
31011 100 µg BRD1, GST-tag
$305
31010 100 µg BRD1, His-tag
$305
31021 100 µg BRD2 (BD1), GST-tag
$305
31022 100 µg BRD2 (BD1), His-tag
$305
32614 384 reactions BRD2 (BD1+BD2) TR-FRET Assay Kit
$510
31024 100 µg BRD2 (BD1+BD2), GST-tag
$305
31025 100 µg BRD2 (BD1+BD2), His-tag
$305
32522 384 reactions BRD2 (BD2) Inhibitor Screening Assay Kit
$510
31023 100 µg BRD2 (BD2), GST-tag
$305
31020 100 µg BRD2 (BD2), His-tag
$305
32513 384 reactions BRD3 (BD1) Inhibitor Screening Assay Kit
$510
31032 100 µg BRD3 (BD1), GST-tag
$305
31030 100 µg BRD3 (BD1), His-tag
$305
32615 384 reactions BRD3 (BD1+BD2) TR-FRET Assay Kit
$510
31035 100 µg BRD3 (BD1+BD2), GST-tag
$305
31034 100 µg BRD3 (BD1+BD2), His-tag
$305
32523 384 reactions BRD3 (BD2) Inhibitor Screening Assay Kit
$510
31033 100 µg BRD3 (BD2), GST-tag
$305
31031 100 µg BRD3 (BD2), His-tag
$305

Items 26 to 50 of 151 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5