Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

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Catalog#SizeProduct NamePrice
32607 384 reactions CREBBP Inhibitor Screening Assay Kit
$495
32610 384 reactions SMARCA2 Inhibitor Screening Assay Kit
$495
32609 384 reactions SMARCA4/BRG1 Inhibitor Screening Assay Kit
$495
32628 384 reactions TAF1 (BD1+BD2) TR-FRET Assay Kit
$495
32604 384 reactions TAF1 (BD1/BD2) Inhibitor Screening Assay Kit
$995
32624 384 reactions TAF1 (BD2) Inhibitor Screening Assay Kit
$995
32627 384 reactions TAF1 (BD2) TR-FRET Assay Kit
$995
32629 384 reactions TAF1L (BD1+BD2) TR-FRET Assay Kit
$995
32603 384 reactions TAF1L (BD1/BD2) Inhibitor Screening Assay Kit
$995
32602 384 reactions TAF1L (BD2) Inhibitor Screening Assay Kit
$995
32606 384 reactions TRIM24 Inhibitor Screening Assay Kit
$995
32630 384 reactions TRIM24 TR-FRET Assay Kit
$995
32631 384 reactions WDR9/BRWD1 TR-FRET Assay Kit
$995
27401 1 mg (+)-JQ1
$50
27400 10 mg (+)-JQ1
$165
27402 5 mg (+)-JQ1
$90
27335 25 mg (-)-JQ1
$640
27334 5 mg (-)-JQ1
$185
33001 10 ml 3x BRD Homogeneous Assay Buffer 1
$190
33007 10 ml 3x BRD Homogeneous Assay Buffer 2
$190
33014 10 ml 3x BRD Homogeneous Assay Buffer 3
$190
33006 10 ml 3x BRD Homogeneous Detection Buffer 2
$190
33015 10 ml 3x BRD Homogeneous Detection Buffer 3
$190
33012 10 ml 3x BRD TR-FRET Assay Buffer 1
$190
33013 10 ml 3x BRD TR-FRET Assay Buffer 2
$190

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