BET Bromodomain Ligand
Catalog #
33000
$475
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Description
The BET Bromodomain Ligand is peptide histone H4 (1-21), acetylated at lysine 5, 8, 12 and 16. It contains a C-terminal GG linker, followed by a biotinylated Lys. This peptide is suitable for use as a ligand for several bromodomains including members of the BET bromodomain family: BRD2, BRD3, BRD4, and BRDT. It also binds to several other bromodomains which are not included in the BET bromodomain family.
This product has been cited 6 times.
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Synonyms
Bromodomain, bromodomain ligand, BET ligand
Product Info
Storage and Usage
Citations6
Purity
≥95%
Supplied As
20 µM aqueous solution
Format
Aqueous buffer solution
Concentration
20 µM
MW
2728.2 Da
Background
Bromodomains function as acetyl-lysine binding domains, and bromodomain/ acetyl-lysine recognition can regulate histone modification, DNA replications, chromatin remodeling, and gene transcription.
References
1. Jasencakova, Z. et al. Plant Cell 12, 2087 (2000).
2. Johnson, C. et al. Nucl Acids Res 26, 994 (1998).
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