BI-9564

Catalog #

82064

$455 *

Size: 25 mg

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

BI-9564 inhibits BRD9 and BRD7 bromodomains and exhibits no significant off-target pharmacology against a panel of 324 kinases and 55 GPCRs at concentrations less than 5 μM. BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC₅₀s = 75 nM and 3.4 μM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo.

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Synonyms

BI9564, BI 9564

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