Spike Neutralizing Antibody (Clone LxC1-G10) (SARS-CoV-2)
This human monoclonal antibody recognizes SARS-CoV-2 full-length spike proteins in both the monomeric (S1) and native trimeric conformation. This antibody has been demonstrated to cross-react with the following SARS-CoV-2 spike proteins:
Wild-type Spike Trimer (BPS Bioscience #100728)
Alpha B.1.1.7 Spike Trimer (BPS Bioscience #510334)
Beta B.1.351 Spike Trimer (BPS Bioscience #510333)
Beta B.1.351Δ242-244 Spike Trimer (BPS Bioscience #101091)
Gamma P.1 Spike Trimer (BPS Bioscience #100989)
Delta B.1.617.2 Spike Trimer (BPS Bioscience #101147)
Delta Plus B.1.617.2.1 Spike Trimer (BPS Bioscience #101165)
Wild-type S1 Protein (BPS Bioscience #100730)
Delta B.1.617.2 S1 Protein (BPS Bioscience #101151)
Delta Plus B.1.617.2.1 S1 Protein (BPS Bioscience #101179)
Gamma P.1 S1 Protein (BPS Bioscience #101079)
[Table of variants]
The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Sike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike Trimer: ACE2 Inhibitor Screening Kits (available for purchase).
Aqueous buffer solution.
1X PBS, 0.2% BSA
The antibody neutralizes the wildtype, Alpha B.1.1.7, Beta B.1.351, Gamma P.1, Delta B.1.617.2 and Delta Plus B.1.617.2.1 variant trimeric proteins. Not tested on other variants or on monomeric Spike RBD protein.
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