PD-1 CHO Cell Line

Catalog #
78530
$7,150 *
Size: 2 vials
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Description

PD-1 CHO Cell Line is a clonal stable CHO-K1 cell line constitutively expressing human PD-1 receptor (accession number: ­­­­­NM_005018). This cell line has been validated for surface expression of human PD-1 by flow cytometry.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
Programmed cell death 1 ligand 1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Product Info
Storage and Usage
Citations
Host Cell Line
CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Supplied As
Each vial contains ≥1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Materials Required But Not Supplied
Name Ordering Information
Thaw Medium 3 BPS Bioscience #60186
Growth Medium 3B BPS Bioscience #79529
UniProt #
Q9NZQ7
Mycoplasma Testing

The cell line has been screened to confirm the absence of Mycoplasma species.

Background

PD-1 (Programmed Death Protein 1, CD279) is a transmembrane protein expressed on the surface of immune cells that binds to PD-L1 or PD-L2, inducing apoptosis of T cells and inhibiting immune responses. Cancer cells often overexpress PD-L1 or PD-L2, allowing them to suppress T cell activation, evade the host immune response, and proliferate. Thus, disrupting the PD-1 co-inhibitory pathways may be an effective approach to developing anti-cancer therapies, as well as other immune diseases like multiple sclerosis, arthritis, lupus, and type I diabetes. The overexpression of PD-1 in this cell line allows for the study of PD-1 antibodies and other novel therapeutics.