Anti-PD-1 (S228P) Neutralizing Antibody

Catalog #
71326
$490 *
Size: 100 µg
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Description

Humanized recombinant anti-PD-1 (IgG4) antibody with S228P mutation, expressed in HEK293 cells. This antibody has not been tested with other species.

This product has been cited 1 time.

Synonyms
PD-1 Neutralizing Antibody, Programmed Cell Death 1, PD1
Product Info
Storage and Usage
Citations1
Species
Human
Isotype
IgG4
Clonality
Monoclonal
Host Species/Expression System
HEK293
Purity

≥90%

Purification
Protein A affinity chromatography from HEK293 supernatants.
Format
Aqueous buffer solution.
Formulation
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
MW
Heavy Chain: 50 kDa, Light Chain: 25 kDa
UniProt #
Q15116
Background
This antibody binds and blocks the activation of the PD-1 receptor. The antibody is humanized, containing a human IgG4 Fc region with an engineered hinge region mutation (S228P) designed to prevent the exchange of IgG4 molecules. This antibody is equivalent to Nivolumab, which has been approved by the FDA for the treatment of melanoma and metastatic squamous non-small cell lung cancer.