PLPro (723-1037), His-tag (SARS-CoV-1) Recombinant
SARS-CoV-1 papain-like protease (PLPro) also known as PLP1, GenBank Accession No. NP_828862.2, a.a. 723-1037, with a N-terminal His-tag, expressed in an E. coli expression system. MW=35 kDa.
≥90%
PBS, 10% glycerol
To date, six human coronaviruses (CoV) have been identified including severe acute respiratory syndrome (SARS) and the SARS-CoV-2, which causes COVID-19 and severe acute respiratory syndrome (SARS).The SARS epidemic of 2002/ 2003 spread to more than 30 countries and had fatality rate of nearly 10%. The SARS genome encodes a number of proteases including papain like protease (PLpro) . Initially, it was reported that SARS PLpro was a deubiquitylase, however subsequent work has shown that PLpro is preferentially a deISGylase. PLpro cleaves ISG15-PLA2 and Ub-PLA2 with high and low efficiency respectively.
1. Nicoloson, B., et al., Protein Science. 2008; 17:1035-1043.
2. Wang, D. et al., JAMA. 2020;323(11): 1061.
Powered by Bioz
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.