PLPro Substrate

Catalog #

79997

$350 *

Size: 1 mg

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

The PLPro (Papain-Like Protease) substrate is a small 5-mer fluorogenic peptide, Z- RLRGG-AMC, used to measure the activity of SARS family PLPro proteases. Release of the C-terminal AMC dye (7-amido-4-methylcoumarin) by proteolysis generates fluorescence, which can be monitored at an excitation wavelength of 345 nm and an emission wavelength of 445 nm.

Conditions optimized for use with:

Papain-like Protease (SARS-CoV-2) Assay Kit: Protease Activity (BPS Bioscience #79995)

The peptide corresponds to a short sequence of ubiquitin and may also be used as substrate of USP5 (isopeptidase T) and ubiquitin C-terminal hydrolases (UCH family, for example UCHL1).

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Synonyms

Z-Arg-Leu-Arg-Gly-Gly-AMC, PLpro substrate, PLP substrate Papain like protease substrate, Benzyloxycarbonyl Arg-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥95%

Supplied As

DMSO, solution

Formulation

DMSO

Concentration

1 mg at 5 mM

Formula

C₄₀H₅₆N₁₂O₉

~840 Da

Amino Acid Sequence

Z-Arg-Leu-Arg-Gly-Gly-AMC

CAS Registry #

167698-69-3

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PLPro Substrate

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