U0126

Catalog #

27012

$250 *

Size: 25 mg

Qty

Bulk/Custom

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Description

U0126 is a selective inhibitor of mitogen-activated protein kinase kinases, MEK-1 and MEK-2. It is a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

This product has been cited 1 time.

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Synonyms

CDK

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Product Data Gallery

Product Info

Storage and Usage

Citations1

Purity

≥99% by HPLC

Format

White to off-white crystalline solid; granular or powder.

Formula

C₁₈H₁₆N₆S₂

380.5 Da

Solubility

Soluble in DMSO at 200 mg/ml. It is poorly soluble in ethanol and water.

Biological Activity

U0126 antagonizes AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 0.07 µM for MEK1 and 0.06 µM for MEK2.

CAS Registry #

109511-58-2

References

1. Favata, M.R., et al., J. Biol. Chem. 1998; 273: 18623 – 18632.
2. DeSilva, D.R., et al., J. Immunol. 1998; 160: 4175 – 4181.
3. Scherle, P.A., et al., J. Immunol. 1998; 161: 5681 – 5686.

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