PKCη (PKCeta), GST-tag Recombinant

Catalog #

40164

$345 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human PKCη (PKCeta), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

PKCL; PKC-L; PRKCL; MGC5363; PRKCH; MGC26269; nPKC-eta, PKCη protein kinase c eta

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

103 kDa

Amino Acids

full length

Genbank #

NM_006255

UniProt #

P24723

Tag(s)

N-terminal GST-tag

Background

PKCη is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCη is predominantly expressed in squamous cell epithelia and induces terminal differentiation of keratinocytes. PKCη that is endogenously expressed or overexpressed is found to associate with the cyclin E/cdk2/p21 complex in keratinocytes of mice and humans (1).

References

Kashiwagi, M. et al: PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes. Oncogene. 2000 Dec 14;19(54):6334-41.

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PKCη (PKCeta), GST-tag Recombinant

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