PKCδ (PKCdelta), GST-tag Recombinant

Catalog #

40161

$345 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human PKCδ (PKCdelta), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

PRKCD; MAY1; MGC49908; nPKC-delta, PKCδ protein kinase c delta

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

104 kDa

Amino Acids

full length

Genbank #

NM_006254

UniProt #

Q05655

Tag(s)

N-terminal GST-tag

Background

Protein kinase C delta (PKCδ) is a member of the protein kinase C (PKC) family of serine-threonine kinases. It is a 79 kd protein kinase that shows strict dependence on the presence of phospholipids, but shows no activation by Ca2+ (1). Phosphatidylinositol is the most potent activator of PKC delta. Northern blot analysis indicated that PKCdelta is widely distributed in almost all the tissues and is a major isoform of PKC expressed in hemopoietic cells (2). PKCdelta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters.

References

1. Leibersperger, H. et al: Immunological demonstration of a calcium-unresponsive protein kinase C of the delta-type in different species and murine tissues. Predominance in epidermis. J Biol Chem. 1991 Aug 5;266(22):14778-84.
2. Mischak, H. et al: Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein. Biochemistry. 1991 Aug 13;30(32):7925-31.

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PKCδ (PKCdelta), GST-tag Recombinant

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