PKCγ (PKCgamma), GST-tag Recombinant

Catalog #

40160

$345 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human PKCγ (PKCgamma), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

PKCC; PKCG; SCA14; MGC57564; PKC-gamma, PKCγ protein kinase c gamma

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

105 kDa

Amino Acids

full length

Genbank #

NM_002739

UniProt #

P05129

Tag(s)

N-terminal GST-tag

Background

PKCγ is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. In the brain, PKCγ is translocated to cell membranes during ischemia and is rapidly removed or degraded during the second otherwise lethal ischemic insult in preconditioned brains. This suggest that ischemic preconditioning enhances downregulation of cell signaling mediated by PKCγ and may thereby provide neuroprotection (1).

References

Shamloo, M. et al: Rapid decline in protein kinase Cgamma levels in the synaptosomal fraction of rat hippocampus after ischemic preconditioning. Neuroreport. 1999 Apr 6;10(5):931-5.

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PKCγ (PKCgamma), GST-tag Recombinant

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