Mouse MEK1 (EE), GST-tag Recombinant

Catalog #

40121

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant mouse MEK1 (S218E, S222E), full length with Serine to Glutamic acid mutations on a.a. 218 and 222 and an N-terminal GST-tag, expressed in E. coli cells.

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Synonyms

MAP2K1; MKK1; MAPKK1; PRKMK1; mitogen activated protein kinase kinase

Product Info

Storage and Usage

Citations

Species

Mouse

Host Species/Expression System

E. coli

Purity

≥95%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

69 kDa

Amino Acids

full length

Genbank #

NM_008927

Tag(s)

N-terminal GST-tag

Background

MEK1 (EE) is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (1). Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer (2).

References

1. Seger, R. et al: The MAPK signaling cascade. FASEB J. 9: 726-735, 1995.
2. Sebolt-Leopold, J S. et al: Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med. 5: 810-816, 1999.

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Mouse MEK1 (EE), GST-tag Recombinant

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