MEK2, GST-tag Recombinant

Catalog #

40125

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human MEK2, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

MAP2K2, MKK2, PRKMK2, MAPKK2; mitogen activated protein kinase kinase 2

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

71 kDa

Amino Acids

full length

Genbank #

NM_030662

UniProt #

P36507

Tag(s)

N-terminal GST-tag

Background

MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways (1). Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation (2).

References

1. Shuichan, Xu et al: Differential Regulation of Mitogen-Activated Protein/ERK Kinase (MEK)1 and MEK2 and Activation by a Ras-Independent Mechanism. Mol. Endocrinol. 1997;11 (11): 1618-1625.
2. Louis-François, B, et al: Mek2 Is Dispensable for Mouse Growth and Development. Mol. Cellular Biol. 2003; 23 (14): 4778-4787.

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MEK2, GST-tag Recombinant

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