Apoptosis

 

Apoptosis is the process of programmed cell death. During apoptosis, a cell initiates intracellular signaling in response to a strong stress or other cue. Death via apoptosis is characterized by many phenotypic changes in a cell, including cell shrinking, nuclear and chromosomal fragmentation, and PARP cleavage. Apoptosis is critical for proper embryonic development, immune system function, and hormone-dependent atrophy. Many of the most widely used cancer therapeutics activate apoptotic machinery to kill cancer cells. Alternately, inhibitors of apoptosis may also have therapeutic value in preventing unregulated apoptosis in HIV or neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s).

There are two known apoptosis signal transduction pathways – the mitochondrial, or intrinsic pathway, and the death receptor, or extrinsic pathway. Apoptosis via the intrinsic pathway occurs when apoptotic stimuli trigger release of mitochondrial intermembrane proteins and SMAC in to the cytosol. These proteins ultimately coordinate to activate caspases which facilitate the process of programmed cell death. Conversely, apoptosis via the extrinsic pathway, as the name implies, relies on signals from outside of the cell. Specifically, death receptors on the surface of cells engage with their cognate ligands and this interaction leads to activation of signal transduction pathways that can activate caspases directly or indirectly through the Bcl-2 family of proteins.

BPS has a number of apoptosis proteins, assay kits, and inhibitors & activators to suit your research goals. These assay kits are easy to use and excellent for high throughput screening (HTS) applications.

References:

1.  Ouyang, L. et al., Cell Proliferat. 2012; 45(6): 487-498.

 

Apoptosis Subcategories

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Catalog#SizeProduct NamePrice
27762-1 50 mg 2-Methoxyestradiol (2-MeOE2)
$165
27762-2 100 mg 2-Methoxyestradiol (2-MeOE2)
$225
27762-3 300 mg 2-Methoxyestradiol (2-MeOE2)
$380
27315 5 mg Ac-DEVD-CMK
$320
27733-2 50 mg Apoptosis Activator 2
$260
27733-3 100 mg Apoptosis Activator 2
$350
27733-1 25 mg Apoptosis Activator 2
$190
27734-1 10 mg Apoptosis Inhibitor
$145
27734-2 25 mg Apoptosis Inhibitor
$215
27734-3 100 mg Apoptosis Inhibitor
$420
27607-1 10 mg BAM7
$185
27607-2 50 mg BAM7
$460
50222 384 reactions BCL-2 TR-FRET Assay Kit
$765
50272 100 µg BCL-2, His-tag
$405
50223 384 reactions BCL-XL TR-FRET Assay Kit
$765
50273 100 µg BCL-XL, His-tag
$405
100080 100 µg BCL2L10, His-Tag
$405
79587 384 reactions BCL2L2 TR-FRET Assay Kit
$765
100091 100 µg BCL2L2, His-Tag
$405
27738-1 5 mg Bendamustine HCl
$110
27738-2 10 mg Bendamustine HCl
$155
27739-1 100 mg Betulinic acid
$145
27739-2 200 mg Betulinic acid
$200
27739-3 500 mg Betulinic acid
$290
27740-1 25 mg BIBR 1532
$280

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