Apoptosis

 

Apoptosis is the process of programmed cell death. During apoptosis, a cell initiates intracellular signaling in response to a strong stress or other cue. Death via apoptosis is characterized by many phenotypic changes in a cell, including cell shrinking, nuclear and chromosomal fragmentation, and PARP cleavage. Apoptosis is critical for proper embryonic development, immune system function, and hormone-dependent atrophy. Many of the most widely used cancer therapeutics activate apoptotic machinery to kill cancer cells. Alternately, inhibitors of apoptosis may also have therapeutic value in preventing unregulated apoptosis in HIV or neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s).

There are two known apoptosis signal transduction pathways – the mitochondrial, or intrinsic pathway, and the death receptor, or extrinsic pathway. Apoptosis via the intrinsic pathway occurs when apoptotic stimuli trigger release of mitochondrial intermembrane proteins and SMAC in to the cytosol. These proteins ultimately coordinate to activate caspases which facilitate the process of programmed cell death. Conversely, apoptosis via the extrinsic pathway, as the name implies, relies on signals from outside of the cell. Specifically, death receptors on the surface of cells engage with their cognate ligands and this interaction leads to activation of signal transduction pathways that can activate caspases directly or indirectly through the Bcl-2 family of proteins.

BPS has a number of apoptosis proteins, assay kits, and inhibitors & activators to suit your research goals. These assay kits are easy to use and excellent for high throughput screening (HTS) applications.

References:

1.  Ouyang, L. et al., Cell Proliferat. 2012; 45(6): 487-498.

 

Apoptosis Subcategories

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Catalog#SizeProduct NamePrice
27762-3 300 mg 2-Methoxyestradiol (2-MeOE2)
$380
27762-1 50 mg 2-Methoxyestradiol (2-MeOE2)
$165
27762-2 100 mg 2-Methoxyestradiol (2-MeOE2)
$225
27315 5 mg Ac-DEVD-CMK
$320
27733-3 100 mg Apoptosis Activator 2
$460
27733-1 25 mg Apoptosis Activator 2
$190
27733-2 50 mg Apoptosis Activator 2
$290
27734-2 25 mg Apoptosis Inhibitor
$215
27734-3 100 mg Apoptosis Inhibitor
$420
27734-1 10 mg Apoptosis Inhibitor
$135
27607-1 10 mg BAM7
$185
27607-2 50 mg BAM7
$705
50222 384 reactions BCL-2 TR-FRET Assay Kit
$695
50272 100 µg BCL-2, His-tag
$405
50223 384 reactions BCL-XL TR-FRET Assay Kit
$695
50273 100 µg BCL-XL, His-tag
$405
27738-2 10 mg Bendamustine HCl
$155
27738-1 5 mg Bendamustine HCl
$98
27739-2 50 mg Betulinic acid
$200
27739-3 100 mg Betulinic acid
$290
27739-1 25 mg Betulinic acid
$145
27740-2 100 mg BIBR 1532
$475
27740-1 25 mg BIBR 1532
$205
27611-2 10 mg Boc-D-FMK
$280
27611-3 25 mg Boc-D-FMK
$580

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