Betulinic acid

Catalog #

27739-2

$205 *

Size: 200 mg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Betulinic acid is a natural pentacyclic triterpenoid that selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic acid also displays TGR5 agonist activity (EC50 =1.04 µM). Betulinic acid is used to study its potential cardiovascular role in the modulation of endothelium-dependent relaxation. Betulinic acid displays anti-HIV and antitumor activity.

●

Synonyms

Lupatic acid; Betulic acid; Mairin; NSC113090; NSC-113090

●

Product Data Gallery

Product Info

Storage and Usage

Citations

Formula

C₃₀H₄₈O₃

456.7 Da

Solubility

Soluble in DMSO

Biological Activity

Initially reported as a selective inhibitor of human melanoma, betulinic acid was found active against neuroectodermal (neuroblastoma, medulloblastoma, Ewing's sarcoma) and malignant brain tumors, ovarian carcinoma, in human leukemia HL-60 cells, and malignant head and neck squamous cell carcinoma SCC25 and SCC9 cell lines. In contrast, epithelial tumors, such as breast, colon, small cell lung and renal cell carcinomas, as well as T-cell leukemia cells, were completely unresponsive to treatment with betulinic acid.

CAS Registry #

472-15-1

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Betulinic acid

PRODUCTS

SERVICES

RESOURCES

COMPANY