BCL-XL, His-tag Recombinant
Catalog #
50273
$450
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Synonyms
Bcl-Xlong, B cell lymphoma XL, bclxl, bcl-2
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 10% glycerol, 225 mM imidazole and 3 mM DTT.
MW
25 kDa
Amino Acids
1–212
Genbank #
Z23115
UniProt #
Q07817
Background
BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins
encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.
References
1. Meng Y. et al., Mol Cancer Ther. 2008 Jul;7(7):2192-202.
2. Asakura T. et al., Mol Int J Oncol. 2008 Aug;33(2):389-95.
2. Asakura T. et al., Mol Int J Oncol. 2008 Aug;33(2):389-95.